Q2. Once print settings are configured, do they need to be re-configured before being used again?

A2. Print settings do not need to be re-configured.

Use the PS Plug-in driver's or PCL driver's [Favorite Setting] to save the print settings that you configured. Once the print settings are saved, they can be called at any time.

For details, refer to the following.
PS Plug-in driver
Using Favorite Setting
PCL driver
Common Buttons and Settings